High quality embryos are key to IVF pregnancy success. Determining the quality of an embryo involves grading during in vitro development. Grading an embryo for quality is the process of analyzing the development of an embryo and evaluating same.
Dr. Laurence Jacobs only selects and transfers the highest quality embryos through a reliable grading process. Determining embryo quality requires a process of evaluating and assigning a grade through innovative genetic testing techniques.
After several days of development in vitro, embryos are analyzed and graded on the following criteria.
- Number of Cells
- Cell Regularity
- Cell Fragmentation
- Number of Nuclei
Number of Cells
As an embryo develops in vitro, the number of cells it contains will increase. By the third day, 7 to 10 cells will have developed in a quality embryo.
Cells within an embryo should be similar in size to be graded as quality. Cells having significantly different size are indicative of an abnormality.
When parts of a cell within an embryo break away, fragmentation occurs. Some degree of fragmentation is normal to occur, however, over 25 percent is indicative of an abnormality.
Number of Nuclei
Only one nucleus is present in a quality embryo. More than one nucleus is indicative of a chromosomal abnormality.
Embryo Grading Scale
- Good cell regularity with no fragmentation Grade Level 1
- Good cell regularity with little fragmentation Grade Level 2
- Good cell regularity with some fragmentation Grade Level 2.5
- Poor cell regularity with little to no fragmentation Grade Level 3
- Poor cell regularity with heavy fragmentation Grade Level 4
A high quality embryo is one having the lower grade level – Levels 1 and 2. Higher graded embryos – Levels 2.5, 3, and 4 have a low likelihood to implant in the uterine lining and result in a successful pregnancy.
Grading Quality Embryos
Genetic testing is safe for embryos. Neither PGD nor PGS causes harm to the developing embryo. Genetic testing and how embryos are graded is a vital resource for most couples undergoing IVF – especially those with diseases passed on through heredity.
The Infertility Doctor
Contact Dr. Laurence A. Jacobs and discover how optimum embryo grading in conjunction with IVF can help you have a baby. Schedule your initial consultation with Dr. Jacobs by clicking the icon below – or – call 888.325.7389.