ICSI fertilization is used to maximize the rate of fertilization and lessen the chances of sperm not being able to penetrate the wall of the egg. ICSI – Intracytoplasmic Sperm Injection – is an intricate egg fertilization technique used during the IVF Process.
How ICSI Fertilization Works
ICSI bypasses a number of reproductive conditions impeding sperm from fertilizing an egg. A single sperm cell is injected directly into an egg under the guidance of a microscope. ICSI is the primary treatment method used for overcoming male-factor infertility.
Candidates for ICSI
ICSI is the fertilization method of choice for most couples undergoing IVF, especially these candidates:
- Unexplained infertility – known as idiopathic infertility – when the cause cannot be pinpointed
- Male-factor infertility – a man’s sperm is not able to fertilize a woman’s egg (40 percent of cases)
- Combined female- and male-factor infertility
ICSI Process Explained
The ICSI procedure takes place in a special laboratory environment having quality controlled temperature and air quality – all conditions are sterile.
- Ovarian stimulation phase
- Surgical egg retrieval phase
- Selection of mature eggs
- A semen sample is typically collected through masturbation
- Sperm can also be micro-surgically removed directly from the testis or epididymis of the testicle (MESA, TESE, PESA)
- After the semen sample has been prepared, a single sperm is picked up into a tiny glass pipette under the guidance of a microscope
- The semen sample is processed in a special solution
- The sperm is injected directly into the cytoplasm of a mature egg (oocyte) by passing the pipette through the surface of the egg
- The sperm cell is released into the egg and the pipette is withdrawn
- Simultaneously, a second polar body is released from the egg
- Monitoring of eggs in vitro until normal embryonic development is confirmed
- Identification and transfer of only quality embryos to the uterus
- Cryopreservation of excess quality embryos for future Frozen Embryo Transfer (FET) procedures
Success Rates of ICSI = 70 Percent
The rates of fertilization success after ICSI are comparable or better than those IVF procedures performed without ICSI. Fertilization may not occur normally when eggs are of a poor quality. Normal fertilization will occur in healthy, mature, high quality eggs in 70 percent of ICSI cases.
ICSI Fertilization Method Expertise
If you would like to know more about ICSI and its effectiveness in successful egg fertilization through IVF, please contact Dr. Laurence A. Jacobs.
The Infertility Doctor has recently opened an office in beautiful Hoffman Estates. Fertility Centers of Illinois has 10 fertility clinic locations and 2 IVF centers located in the Chicagoland area. After you consult with Dr. Jacobs, you can choose from all convenient locations to pursue your customized treatment plan.
Click the icon below to schedule your consultation with Dr. Laurence Jacobs – or – call 888.325.7389.