Why Only Quality Embryos Increase IVF Pregnancy Success

Blastocyst Stage EmbryoTo increase your chance of IVF pregnancy success, only the highest quality embryos must be identified and successfully transferred or cryopreserved. A reliable embryo grading process is a necessity. Determining the quality of an embryo involves an intricate grading process during in vitro development. Grading an embryo for quality is the process of analyzing the development of an embryo and evaluating same.

Quality Embryos

Dr. Laurence Jacobs only selects and transfers the highest quality embryos through a reliable grading process. Determining embryo quality requires a process of evaluating and assigning a grade through innovative genetic testing techniques.

  • Preimplantation Genetic Diagnosis (PGD)
  • Preconception Genetic Screening (PGS)

After several days of development in vitro, embryos are analyzed and graded on the following criteria.

  • Number of Cells
  • Cell Regularity
  • Cell Fragmentation
  • Number of Nuclei

Number of Cells

As an embryo develops in vitro, the number of cells it contains will increase. By the third day, 7 to 10 cells will have developed in a quality embryo.

Cell Regularity

Cells within an embryo should be similar in size to be graded as quality. Cells having significantly different size are indicative of an abnormality.

Cell Fragmentation

When parts of a cell within an embryo break away, fragmentation occurs. Some degree of fragmentation is normal to occur, however, over 25 percent is indicative of an abnormality.

Number of Nuclei

Only one nucleus is present in a quality embryo. More than one nucleus is indicative of a chromosomal abnormality.

Embryo Grading Scale

  • Good cell regularity with no fragmentation             Grade Level 1
  • Good cell regularity with little fragmentation             Grade Level 2
  • Good cell regularity with some fragmentation             Grade Level 2.5
  • Poor cell regularity with little to no fragmentation Grade Level 3
  • Poor cell regularity with heavy fragmentation             Grade Level 4

A high quality embryo is one having the lower grade level – Levels 1 and 2. Higher graded embryos – Levels 2.5, 3, and 4 have a low likelihood to implant in the uterine lining and result in a successful pregnancy.

Grading Quality Embryos

Genetic testing is safe for embryos. Neither PGD nor PGS causes harm to the developing embryo. Genetic testing and how embryos are graded is a vital resource for most couples undergoing IVF – especially those with diseases passed on through heredity.

The Infertility Doctor

Contact Dr. Laurence A. Jacobs and discover how optimum embryo grading in conjunction with IVF can help you have a baby. Schedule your initial consultation with Dr. Jacobs by clicking the icon below – or – call 888.325.7389.

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