Several studies have demonstrated a dramatic increase in sperm DNA fragmentation in obese men, leading to a significant reduction in sperm quality. In addition, there may also be an increase in the miscarriage rate for men with high level fragmented DNA damage. Increased sperm DNA fragmentation due to oxidative stress may be due to several factors: men over age 50; possibly cigarette smoke, excessive exposure to heat; obesity and numerous environmental toxins.
Some of this sperm DNA fragmentation may be reversed. We often recommend various antioxidants (such as CoQ10 or Conception XR or Male Fertility Supplement-MFS) to improve sperm counts, motility and possibly morphology before doing inseminations or in vitro fertilization.
by Laurence A. Jacobs MD